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Target
DNA topoisomerase I/type IB small subunit
Ligand
BDBM246592
Substrate
n/a
Meas. Tech.
Preincubation Relaxation Assay
pH
7.5±n/a
IC50
1.7e+4± 4.2e+3 nM
Comments
extracted
Citation
 Sharma, G; Chowdhury, S; Sinha, S; Majumder, HK; Kumar, SV Antileishmanial activity evaluation of bis-lawsone analogs and DNA topoisomerase-I inhibition studies. J Enzyme Inhib Med Chem 29:185-9 (2014) [PubMed]  Article 
Target
Name:
DNA topoisomerase I/type IB small subunit
Synonyms:
DNA topoisomerase IB
Type:
Protein
Mol. Mass.:
n/a
Description:
Bi-subunit type IB topoisomerase
Components:
This complex has 2 components.
Component 1
Name:
DNA topoisomerase type IB small subunit
Synonyms:
DNA topoisomerase IB small subunit
Type:
Protein
Mol. Mass.:
28120.90
Organism:
Leishmania donovani
Description:
E9B7X3
Residue:
262
Sequence:
MQPVQSPPVAPPSVPVAAPKKTPIDISALKLKMSPSVRATLAAAGVLGQCPRPIEAADEDALLKLKPMKTMVPSVKKVVAPVATTAPPPKVRRVESSSSSSSDSSSSSSDDDSSSDDSSGSDSSSYSSDDRSSSSAESVVSGEATLFHIAQSQGLVNKEVLTQEEEEVPTLVPPRPPVVRSFPNDIGKALERYRERLNREESIIRIKDDNKAVSLGTSKINYIDPRIICSWAKAQDVPINKIFSATIQKKFPWAMNAENFDF
  
Component 2
Name:
DNA topoisomerase I
Synonyms:
DNA topoisomerase IB large subunit
Type:
Protein
Mol. Mass.:
73610.41
Organism:
Leishmania donovani
Description:
E9BRC0
Residue:
635
Sequence:
MKVENSKMGVKREQSHSNEDEEINEEDLNWWEQENLRIAMKGERRWETLAHNGVLFPPEYEPHGIPIFYDGREFKMTPEEEEVATMFAVMKEHDYYRMEVFRRNFFESWREILDKRQHPIRRLELCDFEPIYQWHLVQREKKLSRTKEEKKAIKEKQDAEAEPYRYCVWDGRREQVANFRVEPPGLFRGRGKHPLMGKLKVRVQPEDITINIGETAEVPVPPAGHKWAAVQHDHTVTWLAMWRDSVAGNMKYVMLAPSSSVKGQSDMVKFEKARKLKDKVDDIRASYMEDFKSNDLHVAQRAVAMYFIDRLALRVGNEKGEDEADTVGCCSLRVEHIQLMPDNIVRFDFLGKDSIRYQNDVAVLPEVYALLQRFTRRKSPGTDIFDQLNPTQLNDHLKSFMDGLSAKVFRTYNASITLDRWFKEKPVDPKWSTADKLAYFNKANTEVAILCNHQKSVSKNFKLQMMQLTTKSEYTRKTIELLEKAEVTAKKKSVEEAAKEFLEEQDRMQREWLESYGTEEQKKEFEEIVAKRAAPRVRSEKKKSTSGAKKAESASGKKRAAKKKKSAKKGGKVLSKKAASKSSKKAPKKLKEEDEDDVPLVSVAAKTKKTAGVKRQRANKVVSDDDDVPLAALRV
  
Inhibitor
Name:
BDBM246592
Synonyms:
Bi-lawsone analog, 3b
Type:
Small organic molecule
Emp. Form.:
C29H21NO6
Mol. Mass.:
479.4801
SMILES:
CN(C)c1ccc(cc1)C(C1=C(O)C(=O)c2ccccc2C1=O)C1=C(O)C(=O)c2ccccc2C1=O |c:11,26|
Structure:
Search PDB for entries with ligand similarity: