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Target
Amyloid-beta precursor protein [672-711]
Ligand
BDBM250503
Substrate
n/a
Meas. Tech.
Electrochemiluminescence (ECL)-Based Immunoassay
pH
7±n/a
IC50
397.0±n/a nM
Comments
extracted
Citation
 Pissarnitski, D; Zhao, Z Spirocyclic sulfones as gamma secretase inhibitors US Patent  US9464103 Publication Date 10/11/2016 
Target
Name:
Amyloid-beta precursor protein [672-711]
Synonyms:
A4 | A4_HUMAN | AD1 | APP | Beta-amyloid protein 40
Type:
Enzyme
Mol. Mass.:
4328.29
Organism:
Homo sapiens (Human)
Description:
aa 672-711
Residue:
40
Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  
Inhibitor
Name:
BDBM250503
Synonyms:
US9464103, (6'R,6aR,7r,10aS)-1,4-difluoro-6'-methyl-10a-[4-(trifluoromethyl)benzenesulfonyl]-6,6a,8,9,10,10a-hexahydrospiro[benzo[c]isochromene-7,3'-[1,5,6λ⁵]dioxaphosphinane]-6'-one
Type:
Small organic molecule
Emp. Form.:
C23H22F5O6PS
Mol. Mass.:
552.448
SMILES:
C[P@@]1(=O)OC[C@]2(CCC[C@@]3([C@H]2COc2c(F)ccc(F)c32)S(=O)(=O)c2ccc(cc2)C(F)(F)F)CO1 |r|
Structure:
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