Reaction Details
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Amyloid-beta precursor protein [672-711]
Ligand
BDBM250505
Substrate
n/a
Meas. Tech.
Electrochemiluminescence (ECL)-Based Immunoassay
pH
7±n/a
IC50
5.4±n/a nM
Comments
extracted
Citation
Pissarnitski, D; Zhao, Z Spirocyclic sulfones as gamma secretase inhibitors US Patent US9464103 Publication Date 10/11/2016 More Info.:
Target
Name:
Amyloid-beta precursor protein [672-711]
Synonyms:
A4 | A4_HUMAN | AD1 | APP | Beta-amyloid protein 40
Type:
Enzyme
Mol. Mass.:
4328.29
Organism:
Homo sapiens (Human)
Description:
aa 672-711
Residue:
40
Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Inhibitor
Name:
BDBM250505
Synonyms:
US9464103, (6aR,7S,10aS)-10a-(4-chlorobenzenesulfonyl)-1,4-difluoro-7'-methyl-6,6a,8,9,10,10a-hexahydrospiro[benzo[c]isochromene-7,3'-[1,6,7λ⁵]dioxaphosphepane]-7'-one
Type:
Small organic molecule
Emp. Form.:
C23H24ClF2O6PS
Mol. Mass.:
532.922
SMILES:
CP1(=O)OCC[C@]2(CCC[C@@]3([C@H]2COc2c(F)ccc(F)c32)S(=O)(=O)c2ccc(Cl)cc2)CO1 |r,w:1.0|
Structure:
