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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM254914
Substrate
n/a
Meas. Tech.
AlphaLisa Binding Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
13±n/a nM
Comments
extracted
Citation
 Albrecht, BK; Hewitt, MC; Gehling, VS; Vaswani, RG Benzo [C] isoxazoloazepine bromodomain inhibitors and uses thereof US Patent  US9493483 Publication Date 11/15/2016 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM254914
Synonyms:
US9493483, 402
Type:
Small organic molecule
Emp. Form.:
C26H24ClN5O2
Mol. Mass.:
473.954
SMILES:
CN(C)C(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(ccc2-c2c(C)noc12)-c1cnn(C)c1 |r,t:7|
Structure:
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