Reaction Details Report a problem with these data
Target
Ribosomal protein S6 kinase alpha-3 [399-740,C436V]
Ligand
BDBM259812
Substrate
n/a
Meas. Tech.
RSK2 Inhibition Assay
pH
8±n/a
Temperature
295.15±n/a K
IC50
40000±n/a nM
Comments
extracted
Citation
 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S Kinase inhibitors US Patent  US9505766 Publication Date 11/29/2016 
Target
Name:
Ribosomal protein S6 kinase alpha-3 [399-740,C436V]
Synonyms:
ISPK1 | KS6A3_HUMAN | MAPKAPK1B | RPS6KA3 | RSK2 | Ribosomal S6 kinase 2 (RSK-2)(C436V)
Type:
Enzyme
Mol. Mass.:
38431.12
Organism:
Homo sapiens (Human)
Description:
aa 399-740; RSK2 C-terminal kinase domain (CTD)
Residue:
342
Sequence:
MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL
  
Inhibitor
Name:
BDBM259812
Synonyms:
US9505766, 12
Type:
Small organic molecule
Emp. Form.:
C18H12N4O2
Mol. Mass.:
316.3135
SMILES:
NC(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N
Structure:
Search PDB for entries with ligand similarity: