Reaction Details Report a problem with these data
Target
Replication protein A 70 kDa DNA-binding subunit
Ligand
BDBM61188
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
20300±10700 nM
Citation
 Turchi, JJ; Shuck, S Materials and method for inhibiting replication protein A and uses thereof US Patent  US9533969 Publication Date 1/3/2017 
Target
Name:
Replication protein A 70 kDa DNA-binding subunit
Synonyms:
REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein
Type:
Enzyme
Mol. Mass.:
68139.43
Organism:
Homo sapiens (Human)
Description:
P27694
Residue:
616
Sequence:
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYREYGRRLVMSIRRSALM
  
Inhibitor
Name:
BDBM61188
Synonyms:
4-[5-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phenyl-4-pyrazolyl]-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid | 4-[5-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phenyl-pyrazol-4-yl]-3,4-dihydropyrazol-2-yl]-4-oxidanylidene-butanoic acid | 4-[5-(4-methylphenyl)-3-[3-(4-methylphenyl)-1-phenylpyrazol-4-yl]-3,4-dihydropyrazol-2-yl]-4-oxobutanoic acid | 4-keto-4-[5-[1-phenyl-3-(p-tolyl)pyrazol-4-yl]-3-(p-tolyl)-2-pyrazolin-1-yl]butyric acid | MLS000680473 | SMR000324613 | US9533969, TDRL-520 | cid_5055219
Type:
Small organic molecule
Emp. Form.:
C30H28N4O3
Mol. Mass.:
492.5683
SMILES:
Cc1ccc(cc1)C1=NN(C(C1)c1cn(nc1-c1ccc(C)cc1)-c1ccccc1)C(=O)CCC(O)=O |t:8|
Structure:
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