Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM406220
Substrate
n/a
Meas. Tech.
In Vitro Measurements of human D-Amino Acid Oxidase (DAAO) Activities
IC50
5500±n/a nM
Citation
 Tsai, GE; Wang, C; Hsieh, Y D-amino acid oxidase inhibitors and therapeutic uses thereof US Patent  US10336724 Publication Date 7/2/2019 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM406220
Synonyms:
6-(hydroxymethyl)-4-oxo-4H-pyran-3-yl 4H-furo[3,2-b]pyrrole-5-carboxylate | US10336724, Compound 9
Type:
Small organic molecule
Emp. Form.:
C13H9NO6
Mol. Mass.:
275.2137
SMILES:
OCc1cc(=O)c(OC(=O)c2cc3occc3[nH]2)co1
Structure:
Search PDB for entries with ligand similarity: