Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM406224
Substrate
n/a
Meas. Tech.
In Vitro Measurements of human D-Amino Acid Oxidase (DAAO) Activities
IC50
300±n/a nM
Citation
 Tsai, GE; Wang, C; Hsieh, Y D-amino acid oxidase inhibitors and therapeutic uses thereof US Patent  US10336724 Publication Date 7/2/2019 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM406224
Synonyms:
5-chloro-2-oxo-1,2-dihydroquinolin-3-yl 3-phenethyl-1H-pyrazole-5-carboxylate | US10336724, Compound 27
Type:
Small organic molecule
Emp. Form.:
C21H16ClN3O3
Mol. Mass.:
393.823
SMILES:
Clc1cccc2[nH]c(=O)c(OC(=O)c3cc(CCc4ccccc4)n[nH]3)cc12
Structure:
Search PDB for entries with ligand similarity: