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Target
Hsp90 co-chaperone Cdc37
Ligand
BDBM50180306
Substrate
n/a
Meas. Tech.
Binding to JNPL3 brain Hsp90
EC50
122±n/a nM
Citation
 Chiosis, G; Greengard, P; Dou, F; Luo, W; He, H; Zatorska, D Treatment of neurodegenerative diseases through inhibition of HSP90 US Patent  US10336757 Publication Date 7/2/2019 
Target
Name:
Hsp90 co-chaperone Cdc37
Synonyms:
CDC37 | CDC37A | CDC37_HUMAN | Hsp90 co-chaperone
Type:
Molecular Chaperone
Mol. Mass.:
44453.72
Organism:
Homo sapiens (Human)
Description:
Q16543
Residue:
378
Sequence:
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV
  
Inhibitor
Name:
BDBM50180306
Synonyms:
8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE | 8-(6-bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)adenine | CHEMBL383189 | US10336757, Compound PU-HT64 | US10676476, Example 5
Type:
Small organic molecule
Emp. Form.:
C18H21BrN6O2S
Mol. Mass.:
465.367
SMILES:
CC(C)NCCCn1c(Sc2cc3OCOc3cc2Br)nc2c(N)ncnc12
Structure:
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