Reaction Details Report a problem with these data
Target
Hsp90 co-chaperone Cdc37
Ligand
BDBM406703
Substrate
n/a
Meas. Tech.
Binding to JNPL3 brain Hsp90
EC50
813±n/a nM
Citation
 Chiosis, G; Greengard, P; Dou, F; Luo, W; He, H; Zatorska, D Treatment of neurodegenerative diseases through inhibition of HSP90 US Patent  US10336757 Publication Date 7/2/2019 
Target
Name:
Hsp90 co-chaperone Cdc37
Synonyms:
CDC37 | CDC37A | CDC37_HUMAN | Hsp90 co-chaperone
Type:
Molecular Chaperone
Mol. Mass.:
44453.72
Organism:
Homo sapiens (Human)
Description:
Q16543
Residue:
378
Sequence:
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV
  
Inhibitor
Name:
BDBM406703
Synonyms:
US10336757, Compound PU-HT133
Type:
Small organic molecule
Emp. Form.:
C21H27FN6O2
Mol. Mass.:
414.4765
SMILES:
CCc1cc2OCOc2cc1Cc1nc2c(N)nc(F)nc2n1CCCNC(C)C
Structure:
Search PDB for entries with ligand similarity: