Reaction Details Report a problem with these data
Target
Free fatty acid receptor 2
Ligand
BDBM404121
Substrate
n/a
Meas. Tech.
GTPγS Assay
EC50
>1000±n/a nM
Citation
 Hoveyda, HR; Schils, D; Zoute, L; Parcq, J Substituted pyrrolidines as G-protein coupled receptor 43 agonists US Patent  US10358416 Publication Date 7/23/2019 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM404121
Synonyms:
(2S,4S,5R)-5-(2-chlorophenyl)-4-cyano-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)-4-methylpyrrolidine-2-carboxylic acid | US10017468, Compound 306 | US10781171, Compound 306 | US11072582, Compound 306
Type:
Small organic molecule
Emp. Form.:
C27H23ClN2O4
Mol. Mass.:
474.936
SMILES:
COc1ccccc1-c1ccc(cc1)C(=O)N1[C@@H](C[C@](C)(C#N)[C@@H]1c1ccccc1Cl)C(O)=O
Structure:
Search PDB for entries with ligand similarity: