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Target
Free fatty acid receptor 2
Ligand
BDBM404216
Substrate
n/a
Meas. Tech.
GTPγS Assay
EC50
>1000±n/a nM
Citation
 Hoveyda, HR; Schils, D; Zoute, L; Parcq, J Substituted pyrrolidines as G-protein coupled receptor 43 agonists US Patent  US10358416 Publication Date 7/23/2019 
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM404216
Synonyms:
(2S,5R)-5-(2-chlorophenyl)-1-(1-(2-cyano-4-(methylsulfonamido)phenyl)piperidine-4-carbonyl)pyrrolidine-2-carboxylic acid | US10017468, Compound 391 | US10781171, Compound 391 | US11072582, Compound 391
Type:
Small organic molecule
Emp. Form.:
C25H27ClN4O5S
Mol. Mass.:
531.024
SMILES:
CS(=O)(=O)Nc1ccc(N2CCC(CC2)C(=O)N2[C@@H](CC[C@@H]2c2ccccc2Cl)C(O)=O)c(c1)C#N
Structure:
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