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Target
RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E]
Ligand
BDBM410342
Substrate
n/a
Meas. Tech.
Biological Assays
IC50
<0.002±n/a nM
Citation
 Aversa, RJ; Burger, MT; Dillon, MP; Dineen, Jr., TA; Karki, R; Ramurthy, S; Rauniyar, V; Robinson, R; Sarver, PJ Tricyclic compounds and compositions as kinase inhibitors US Patent  US10377770 Publication Date 8/13/2019 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E]
Synonyms:
C-RAF | Proto-oncogene C-Raf (C-Raf FL) | RAF | RAF proto-oncogene serine/threonine-protein kinase | RAF1 | RAF1_HUMAN
Type:
n/a
Mol. Mass.:
73012.38
Organism:
Homo sapiens (Human)
Description:
P04049[Y340E,Y341E]
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSEEWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM410342
Synonyms:
N-(3-((4aR,6R)-6-Hydroxy-1,2,4,4a,5,6-hexahydro-[1,4]oxazino[4,3-a][1,5]naphthyridin-9-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide and N-(3-((4aS,6S)-6-hydroxy-1,2,4,4a,5,6-hexahydro-[1,4]oxazino[4,3-a][1,5]naphthyridin-9-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide | US10377770, Example 102
Type:
Small organic molecule
Emp. Form.:
C25H23F3N4O3
Mol. Mass.:
484.4703
SMILES:
Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1cnc2[C@H](O)C[C@@H]3COCCN3c2c1 |r|
Structure:
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