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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM25745
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
60.0±n/a nM
Citation
 Guedes, AG; Hammock, BD; Morisseau, C Treatment of inflammatory disorders in non-human mammals US Patent  US10383835 Publication Date 8/20/2019 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
EPHX2 | HYES_PIG | Soluble Epoxide Hydrolase
Type:
n/a
Mol. Mass.:
62766.18
Organism:
Sus scrofa (Pig)
Description:
Q6Q2C2
Residue:
555
Sequence:
MALRAAVFDLDGVLALPSITTSWARAEEKLALPRGFLNEAFKKGGQDGSVARVMTGEITFSQWVPFMEEDCRKCAEDSGIRLPENFSVKHIFDKALSEKKINYPMLQAALTLKKKGFSTCILTNNWLDDSAQRGSRAQLMCELRPHFDFLIESCRVGMAKPDPQIYKLMLDTLKAEPNEVVFLDDVGTHLKPVRDLGMATILVRDTDTALRELEKVTGVQLLQTPALPPTSCDPSALSHGYVLIKPGVRLHFVEMGSGPAVCLCHGFPESWFSWRYQIPALAQAGFRVLAVDMKGYGESSAPPEIEEYSLEVLCKDMVTFLNKLGLSQAVFIGHDWGGVLVWNMALFYPERVRAVASLNTPFMPSNPNVSPMEIIKANPVFDYQLYFQEPGVAEAELEQNLDRTFKNFFRAHDETFLTTNRVRELGGLFVGTPEEPSLSRLVTEEDIQFYVQQFKKSGFRGPLNWYRNMERNWQWGCKGSGRKILIPALMVTAENDLVLHPKMSKHMENWIPHLKRGHIKDCGHWTQIDKPAELNRILIEWLETDARNPLVDSKL
  
Inhibitor
Name:
BDBM25745
Synonyms:
3-(1-methanesulfonylpiperidin-4-yl)-1-[4-(trifluoromethoxy)phenyl]urea | US10383835, Compound 1709 | US9296693, 55 | Urea-based compound, 26
Type:
Small organic molecule
Emp. Form.:
C14H18F3N3O4S
Mol. Mass.:
381.371
SMILES:
CS(=O)(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1
Structure:
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