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Target
Metalloproteinase inhibitor 2
Ligand
BDBM413590
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
53000±n/a nM
Citation
 Prades Cosano, R; Seco Moral, J; Tarragó Clua, MT Gelatinase inhibitors and use thereof US Patent  US10414797 Publication Date 9/17/2019 
Target
Name:
Metalloproteinase inhibitor 2
Synonyms:
Metalloproteinase inhibitor 2 (TIMP2) | TIMP-2 | TIMP2 | TIMP2_CRILO | Tissue inhibitor of metalloproteinases 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21943.02
Organism:
Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster)
Description:
Q60453
Residue:
196
Sequence:
RACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPDKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKSINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
  
Inhibitor
Name:
BDBM413590
Synonyms:
(2S)-2-[[(2S)-1-acetylpyrrolidine-2-carbonyl]-methyl-amino]-N-[(1S)-2-(hydroxyamino)-1-(1H-indol-3-ylmethyl)-2-oxo-ethyl]pentanediamide | US10414797, Comparative Example 20 | US10414797, Example C20
Type:
Small organic molecule
Emp. Form.:
C24H32N6O6
Mol. Mass.:
500.5475
SMILES:
CN([C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NO)C(=O)[C@@H]1CCCN1C(C)=O |r|
Structure:
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