Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM413981
Substrate
n/a
Meas. Tech.
Reporter Displacement Assay
Kd
300±n/a nM
Citation
 Jefson, MR; Lowe, III, JA; Dey, F; Bergmann, A; Schoop, A Heterobicyclic N-aminophenyl-amides as inhibitors of histone deacetylase US Patent  US10421756 Publication Date 9/24/2019 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM413981
Synonyms:
US10421756, Compound 165
Type:
Small organic molecule
Emp. Form.:
C23H29N5O2
Mol. Mass.:
407.5087
SMILES:
Nc1ccc(cc1NC(=O)N1CCC2(CCN(C2)C2COC2)CC1)-c1ccncc1
Structure:
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