Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM414432
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
1.000±n/a nM
Citation
Bothe, U; Siebeneicher, H; Schmidt, N; Günther, J; Steuber, H; Bömer, U; Lange, M; Nubbemeyer, R; Ray, NC; Savy, P 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs US Patent US10435396 Publication Date 10/8/2019
More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM414432
Synonyms:
N-(2-{1-[2-(Dimethylamino)ethyl]piperidin-4-yl}-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)pyridine-2-carboxamide | US10435396, Example 9
Type:
Small organic molecule
Emp. Form.:
C24H29F3N6O2
Mol. Mass.:
490.5213
SMILES:
COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCN(CCN(C)C)CC1