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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM414434
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
3.00±n/a nM
Citation
 Bothe, U; Siebeneicher, H; Schmidt, N; Günther, J; Steuber, H; Bömer, U; Lange, M; Nubbemeyer, R; Ray, NC; Savy, P 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs US Patent  US10435396 Publication Date 10/8/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM414434
Synonyms:
N-[2-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)-6-methoxy-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | US10435396, Example 11
Type:
Small organic molecule
Emp. Form.:
C20H19F3N4O4S
Mol. Mass.:
468.449
SMILES:
COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCS(=O)(=O)CC1
Structure:
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