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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM414459
Substrate
n/a
Meas. Tech.
IRAK4 Kinase Assay
IC50
47.0±n/a nM
Citation
 Bothe, U; Siebeneicher, H; Schmidt, N; Günther, J; Steuber, H; Bömer, U; Lange, M; Nubbemeyer, R; Ray, NC; Savy, P 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs US Patent  US10435396 Publication Date 10/8/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM414459
Synonyms:
N-[6-Chloro-2-(tetrahydro-2H-pyran-4-yl)-2H-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | US10435396, Example 30
Type:
Small organic molecule
Emp. Form.:
C19H16ClF3N4O2
Mol. Mass.:
424.804
SMILES:
FC(F)(F)c1cccc(n1)C(=O)Nc1cc2cn(nc2cc1Cl)C1CCOCC1
Structure:
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