Reaction Details Report a problem with these data
Target
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Ligand
BDBM415401
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
11.6±n/a nM
Citation
 Graham, K; Klar, U; Briem, H; Schulze, V; Siemeister, G; Lienau, P; Tempel, R; Bálint, J 4H-pyrrolo[3,2-C]pyridin-4-one derivatives US Patent  US10428063 Publication Date 10/1/2019 
Target
Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Synonyms:
BUB1 | BUB1L | BUB1_HUMAN | Mitotic checkpoint serine/threonine-protein kinase BUB1 (aa 704-1085)
Type:
n/a
Mol. Mass.:
43624.72
Organism:
Homo sapiens (Human)
Description:
O43683[704-1085]
Residue:
382
Sequence:
DAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK
  
Inhibitor
Name:
BDBM415401
Synonyms:
Intermediate 1-1-1 (4-hydroxy-6,6-dimethyl-2-oxo-N-phenyl-1,2,5,6-tetrahydropyridine-3-carbothioamide) | US10428063, Example 1
Type:
Small organic molecule
Emp. Form.:
C14H16N2O2S
Mol. Mass.:
276.354
SMILES:
CC1(C)CC(O)=C(C(=S)Nc2ccccc2)C(=O)N1 |t:5|
Structure:
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