Target
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Ligand
BDBM415405
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
35.1±n/a nM
Citation
 Graham, KKlar, UBriem, HSchulze, VSiemeister, GLienau, PTempel, RBálint, J 4H-pyrrolo[3,2-C]pyridin-4-one derivatives US Patent  US10428063 Publication Date 10/1/2019 
Target
Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Synonyms:
BUB1 | BUB1L | BUB1_HUMAN | Mitotic checkpoint serine/threonine-protein kinase BUB1 (aa 704-1085)
Type:
n/a
Mol. Mass.:
43624.72
Organism:
Homo sapiens (Human)
Description:
O43683[704-1085]
Residue:
382
Sequence:
DAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK
  
Inhibitor
Name:
BDBM415405
Synonyms:
Example 5 (1-ethyl-3-(phenylamino)-2-(pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one) | US10428063, Example 5
Type:
Small organic molecule
Emp. Form.:
C21H21N3O
Mol. Mass.:
331.4109
SMILES:
CCC1C2=C(C(Nc3ccccc3)=C1c1ccncc1)C(=O)NCC2 |c:3,13|
Structure:
Search PDB for entries with ligand similarity: