Reaction Details
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Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Ligand
BDBM415425
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
17.1±n/a nM
Citation
Graham, K; Klar, U; Briem, H; Schulze, V; Siemeister, G; Lienau, P; Tempel, R; Bálint, J 4H-pyrrolo[3,2-C]pyridin-4-one derivatives US Patent US10428063 Publication Date 10/1/2019 More Info.:
Target
Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 [704-1085]
Synonyms:
BUB1 | BUB1L | BUB1_HUMAN | Mitotic checkpoint serine/threonine-protein kinase BUB1 (aa 704-1085)
Type:
n/a
Mol. Mass.:
43624.72
Organism:
Homo sapiens (Human)
Description:
O43683[704-1085]
Residue:
382
Sequence:
DAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK
Inhibitor
Name:
BDBM415425
Synonyms:
US10428063, Example 25 | US10428063, Example 40 | US20230322767, Example No. 40 WO 2016/120196 | US20230339939, WO 2016/120196, Example 40 | WO 2016/120196, Example 40 | rel-(1R,2R)-2-fluoro-N-{4-[5-methyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}cyclopropanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C23H22FN5O2
Mol. Mass.:
419.4515
SMILES:
CN1CCc2[nH]c(c(Nc3ccccc3)c2C1=O)-c1ccnc(NC(=O)[C@@H]2C[C@@H]2F)c1 |r|
Structure:
