Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 2
Ligand
BDBM278497
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<100±n/a nM
Citation
 Lu, L; Yao, W; He, C; Zhang, F Bicyclic heterocycles as FGFR inhibitors US Patent  US10450313 Publication Date 10/22/2019 
Target
Name:
Fibroblast growth factor receptor 2
Synonyms:
BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2
Type:
Enzyme
Mol. Mass.:
92015.45
Organism:
Homo sapiens (Human)
Description:
P21802
Residue:
821
Sequence:
MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
  
Inhibitor
Name:
BDBM278497
Synonyms:
7-amino-3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-8-(1-methyl-1H-pyrazol-5-yl)-3,4-dihydropyrido[4,3-d]pyrimidin-2(1H)-one | US10040790, Example 13 | US10450313, Example 13 | US10947230, Example 13 | US11530214, Example 13
Type:
Small organic molecule
Emp. Form.:
C20H20F2N6O3
Mol. Mass.:
430.408
SMILES:
COc1cc(OC)c(F)c(N2Cc3cnc(N)c(-c4ccnn4C)c3N(C)C2=O)c1F |(-4.52,5,;-3.19,4.23,;-3.19,2.69,;-4.52,1.93,;-4.52,.38,;-5.85,-.38,;-7.19,.38,;-3.19,-.38,;-3.19,-1.93,;-1.85,.38,;-.52,-.38,;-.52,-1.93,;.82,-2.69,;.82,-4.23,;2.15,-5,;3.48,-4.23,;4.82,-5,;3.48,-2.69,;4.82,-1.93,;4.82,-.38,;6.28,.09,;7.19,-1.15,;6.28,-2.4,;7.05,-3.73,;2.15,-1.93,;2.15,-.38,;3.48,.38,;.82,.38,;.82,1.93,;-1.85,1.93,;-.52,2.69,)|
Structure:
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