Reaction Details Report a problem with these data
Target
Histone-lysine N-methyltransferase SUV39H2
Ligand
BDBM423069
Substrate
n/a
Meas. Tech.
Suv 39H2 Assay
IC50
6.72±n/a nM
Citation
 Matsuo, Y; Hisada, S; Nakamura, Y; Chakrabarti, A; Rawat, M; Rai, S; Satyanarayana, AV; Duan, Z; Talukdar, A; Ravula, S; Decornez, H Bicyclic compound and use thereof for inhibiting SUV39H2 US Patent  US10508109 Publication Date 12/17/2019 
Target
Name:
Histone-lysine N-methyltransferase SUV39H2
Synonyms:
H3-K9-HMTase 2 | Histone H3-K9 methyltransferase 2 | Histone-lysine N-methyltransferase SUV39H2 | Histone-lysine N-methyltransferase SUV39H2 (Suv39H2) | KMT1B | Lysine N-methyltransferase 1B | SUV39H2 | SUV92_HUMAN | Su(var)3-9 homolog 2 | Suppressor of variegation 3-9 homolog 2
Type:
Enzyme
Mol. Mass.:
46692.47
Organism:
Homo sapiens (Human)
Description:
Q9H5I1
Residue:
410
Sequence:
MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
  
Inhibitor
Name:
BDBM423069
Synonyms:
2-(5-chloro-4-methoxy-2- ((methylthio)methoxy)phenyl)- 7-(4-(cyclopropylsulfonyl)- piperazin-1-yl)imidazo[1,2- a]pyridine | US10508109, Example 255
Type:
Small organic molecule
Emp. Form.:
C23H27ClN4O4S2
Mol. Mass.:
523.068
SMILES:
COc1cc(OCSC)c(cc1Cl)-c1cn2ccc(cc2n1)N1CCN(CC1)S(=O)(=O)C1CC1
Structure:
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