Reaction Details Report a problem with these data
Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM423209
Substrate
n/a
Meas. Tech.
Electrophysiology Assay
IC50
4.70±n/a nM
Citation
 Yadav, ND; Bhide, RS; Bora, RO; Gunaga, P; Panda, M; Priestley, ES; Richter, J Substituted nitrogen containing compounds US Patent  US10501449 Publication Date 12/10/2019 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM423209
Synonyms:
(R)-4-methyl-5-(4-((6- (4-methyl-1H-imidazol- 1-yl)pyridin-3-yl) methyl)piperazin-2-yl)iso- benzofuran-1(3H)-one | US10501449, Example 66-I
Type:
Small organic molecule
Emp. Form.:
C23H25N5O2
Mol. Mass.:
403.4769
SMILES:
Cc1cn(cn1)-c1ccc(CN2CCN[C@@H](C2)c2ccc3C(=O)OCc3c2C)cn1 |r|
Structure:
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