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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM423343
Substrate
n/a
Meas. Tech.
TDO and IDO Biochemical Coupled Assay
IC50
<300±n/a nM
Citation
 Cowley, PM; Wise, A; Brown, TJ; McGowan, MA; Zhou, H; Han, Y Substituted bicyclic fused ring compounds as indoleamine-2,3-dioxygenase inhibitors US Patent  US10501458 Publication Date 12/10/2019 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM423343
Synonyms:
US10501458, Compound 1016
Type:
Small organic molecule
Emp. Form.:
C14H19ClN4O2S
Mol. Mass.:
342.844
SMILES:
CC1(C)CN(CCN1S(C)(=O)=O)c1cc(Cl)cn2cncc12
Structure:
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