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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM377208
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<100±n/a nM
Citation
 Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as PIM kinase inhibitors US Patent  US10517858 Publication Date 12/31/2019 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM377208
Synonyms:
N-{4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(4-ethoxy-2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide | US10265307, Example 51-1 | US10517858, Example 51 (Diastereoisomer 1) | US10828290, Example 51 (Diastereoisomer 1) | US11229631, Example 51 Diastereoisomer 1
Type:
Small organic molecule
Emp. Form.:
C28H30F3N5O4
Mol. Mass.:
557.5641
SMILES:
CCOc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnc2[C@@H](O)CCc2c1N1C[C@H](C)[C@@H](O)[C@H](N)C1 |r,wU:25.27,37.41,33.37,wD:35.39,(5.19,7.53,;5.19,5.99,;3.85,5.22,;3.85,3.68,;2.52,2.91,;2.52,1.37,;1.18,.6,;3.85,.6,;5.19,1.37,;6.52,.6,;5.19,2.91,;3.85,-.94,;2.52,-1.71,;2.52,-3.25,;3.85,-4.02,;5.19,-3.25,;5.19,-1.71,;6.52,-.94,;1.18,-4.02,;1.18,-5.56,;-.15,-3.25,;-1.48,-4.02,;-1.48,-5.56,;-2.82,-6.33,;-4.15,-5.56,;-5.61,-6.04,;-6.01,-7.53,;-6.52,-4.79,;-5.61,-3.55,;-4.15,-4.02,;-2.82,-3.25,;-2.82,-1.71,;-1.48,-.94,;-1.48,.6,;-.15,1.37,;-2.82,1.37,;-2.82,2.91,;-4.15,.6,;-5.48,1.37,;-4.15,-.94,)|
Structure:
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