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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM377212
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<100±n/a nM
Citation
 Xue, C; Li, Y; Feng, H; Zhang, K Thiazolecarboxamides and pyridinecarboxamide compounds useful as PIM kinase inhibitors US Patent  US10517858 Publication Date 12/31/2019 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM377212
Synonyms:
US10265307, Example 53-2 | US10517858, Example 53 (Diastereoisomer 2) | US10828290, Example 53 (Diastereoisomer 2)
Type:
Small organic molecule
Emp. Form.:
C24H26F2N6O3S
Mol. Mass.:
516.563
SMILES:
COc1ccc(F)c(-c2nc(C(=O)Nc3cnc4[C@H](O)CCc4c3N3CCC[C@H](N)C3)c(N)s2)c1F |r|
Structure:
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