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Target
Bromodomain-containing protein 4 [44-164]
Ligand
BDBM425390
Substrate
n/a
Meas. Tech.
Alphascreen Binding Assay
IC50
<1000±n/a nM
Citation
 Zhang, J; Buell, J; Chan, K; Ibrahim, PN; Lin, J; Pham, P; Shi, S; Spevak, W; Wu, G; Wu, J Heterocyclic compounds and uses thereof US Patent  US10519177 Publication Date 12/31/2019 
Target
Name:
Bromodomain-containing protein 4 [44-164]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (aa 44-164) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14412.06
Organism:
Homo sapiens (Human)
Description:
BRD4-BD1 (44-164)
Residue:
121
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL
  
Inhibitor
Name:
BDBM425390
Synonyms:
4-[1-[(4,4-difluorocyclohexyl)methyl]- 3-[1-(oxetan-3-yl)pyrazol-4- yl]pyrrolo[3,2-b]pyridin-6-yl]-3,5- dimethyl-isoxazole | US10519177, Compound P-0295
Type:
Small organic molecule
Emp. Form.:
C25H27F2N5O2
Mol. Mass.:
467.511
SMILES:
Cc1noc(C)c1-c1cnc2c(cn(CC3CCC(F)(F)CC3)c2c1)-c1cnn(c1)C1COC1
Structure:
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