Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [44-164]
Ligand
BDBM425422
Substrate
n/a
Meas. Tech.
Alphascreen Binding Assay
IC50
<1000±n/a nM
Citation
 Zhang, J; Buell, J; Chan, K; Ibrahim, PN; Lin, J; Pham, P; Shi, S; Spevak, W; Wu, G; Wu, J Heterocyclic compounds and uses thereof US Patent  US10519177 Publication Date 12/31/2019 
Target
Name:
Bromodomain-containing protein 4 [44-164]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (aa 44-164) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14412.06
Organism:
Homo sapiens (Human)
Description:
BRD4-BD1 (44-164)
Residue:
121
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL
  
Inhibitor
Name:
BDBM425422
Synonyms:
4-[1-benzyl-3-(1-methylpyrazol-4- yl)pyrrolo[3,2-b]pyridin-6-yl]-3,5- dimethyl-isoxazole | US10519177, Compound P-0327
Type:
Small organic molecule
Emp. Form.:
C23H21N5O
Mol. Mass.:
383.4457
SMILES:
Cc1noc(C)c1-c1cnc2c(cn(Cc3ccccc3)c2c1)-c1cnn(C)c1
Structure:
Search PDB for entries with ligand similarity: