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Target
Bromodomain-containing protein 4 [44-164]
Ligand
BDBM425463
Substrate
n/a
Meas. Tech.
Alphascreen Binding Assay
IC50
<1000±n/a nM
Citation
 Zhang, J; Buell, J; Chan, K; Ibrahim, PN; Lin, J; Pham, P; Shi, S; Spevak, W; Wu, G; Wu, J Heterocyclic compounds and uses thereof US Patent  US10519177 Publication Date 12/31/2019 
Target
Name:
Bromodomain-containing protein 4 [44-164]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (aa 44-164) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
14412.06
Organism:
Homo sapiens (Human)
Description:
BRD4-BD1 (44-164)
Residue:
121
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL
  
Inhibitor
Name:
BDBM425463
Synonyms:
3-[1-[dideuterio-(4,4- difluorocyclohexyl)methyl]-6-(3,5- dimethylisoxazol-4-yl)pyrrolo[3,2- b]pyridin-3-yl]prop-2-yn-1-ol | US10519177, Compound P-0370
Type:
Small organic molecule
Emp. Form.:
C24H26F2N2O
Mol. Mass.:
396.4728
SMILES:
CC1=CC=C(C)C1c1cnc2c(cn(CC3CCC(F)(F)CC3)c2c1)C#CCO |t:1,3|
Structure:
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