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Target
Thyroid hormone receptor beta
Ligand
BDBM426634
Substrate
n/a
Meas. Tech.
transactivation assay
EC50
0.880±1.12 nM
Citation
 Scanlan, T; Devereaux, J; Placzek, A; Banerji, T; Ferrara, S; Meinig, JM; Banerji, T Derivatives of sobetirome US Patent  US10544075 Publication Date 1/28/2020 
Target
Name:
Thyroid hormone receptor beta
Synonyms:
ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:
Receptor
Mol. Mass.:
52793.62
Organism:
Homo sapiens (Human)
Description:
Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:
461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
  
Inhibitor
Name:
BDBM426634
Synonyms:
US10544075, Compound JD-20
Type:
Small organic molecule
Emp. Form.:
C18H18Br2O4
Mol. Mass.:
458.141
SMILES:
CC(C)c1cc(Cc2c(Br)cc(OCC(O)=O)cc2Br)ccc1O
Structure:
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