Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM361134
Substrate
n/a
IC50
0.069±n/a nM
Citation
 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Metallo-beta-lactamase inhibitors US Patent  US10544130 Publication Date 1/28/2020 
Target
Name:
Beta-lactamase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29508.45
Organism:
n/a
Description:
Q2QC95
Residue:
266
Sequence:
MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
 
Inhibitor
Name:
BDBM361134
Synonyms:
(R)-4-(imidazo[1,2- a]pyridin-8-yl)-N1- (pyrrolidin-3-yl)-3-(2H- tetrazol-5-yl)benzene- 1,2-disulfonamide | US10221163, Example 291 | US10544130, Example 291
Type:
Small organic molecule
Emp. Form.:
C18H19N9O4S2
Mol. Mass.:
489.531
SMILES:
NS(=O)(=O)c1c(ccc(-c2cccn3ccnc23)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1 |r|
Structure:
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