Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM361314
Substrate
n/a
IC50
0.073±n/a nM
Citation
 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Metallo-beta-lactamase inhibitors US Patent  US10544130 Publication Date 1/28/2020 
Target
Name:
Beta-lactamase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29508.45
Organism:
n/a
Description:
Q2QC95
Residue:
266
Sequence:
MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
 
Inhibitor
Name:
BDBM361314
Synonyms:
(R)-2-((4′-(N-(pyrrolidin-3-yl)sulfamoyl)-3′-sulfamoyl-2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-yl)amino)thiazole-4-carboxamide | BDBM427635 | US10221163, Example 471
Type:
Small organic molecule
Emp. Form.:
C21H22N10O5S3
Mol. Mass.:
590.658
SMILES:
NC(=O)c1csc(Nc2cccc(c2)-c2ccc(c(c2-c2nn[nH]n2)S(N)(=O)=O)S(=O)(=O)N[C@@H]2CCNC2)n1 |r|
Structure:
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