Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM361333
Substrate
n/a
IC50
0.101±n/a nM
Citation
 Bennett, F; Jiang, J; Pasternak, A; Dong, S; Gu, X; Scott, JD; Tang, H; Zhao, Z; Huang, Y; Yang, D; Young, K; Xiao, L; Zhang, Z; Fu, J Metallo-beta-lactamase inhibitors US Patent  US10544130 Publication Date 1/28/2020 
Target
Name:
Beta-lactamase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29508.45
Organism:
n/a
Description:
Q2QC95
Residue:
266
Sequence:
MKTFAAYVIIACLSSTALAGSITENTSWNKEFSAEAVNGVFVLCKSSSKSCATNDLARASKEYLPASTFKIPNAIIGLETGVIKNEHQVFKWDGKPRAMKQWERDLTLRGAIQVSAVPVFQQIAREVGEVRMQKYLKKFSYGNQNISGGIDKFWLEGQLRISAVNQVEFLESLYLNKLSASKENQLIVKEALVTEAAPEYLVHSKTGFSGVGTESNPGVAWWVGWVEKETEVYFFAFNMDIDNESKLPLRKSIPTKIMESEGIIGG
 
Inhibitor
Name:
BDBM361333
Synonyms:
(R)-4-(6-aminopyridin-3- yl)-N1-(piperidin-3-yl)-3- (2H-tetrazol-5- yl)benzene-1,2- disulfonamide | US10221163, Example 490 | US10544130, Example 490
Type:
Small organic molecule
Emp. Form.:
C17H21N9O4S2
Mol. Mass.:
479.537
SMILES:
Nc1ccc(cn1)-c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCCNC1 |r|
Structure:
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