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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM283924
Substrate
n/a
Meas. Tech.
IRAK4 Inhibition Assay
IC50
2.80±n/a nM
Citation
 Bhide, RS; Duncia, JV; Hynes, J; Nair, SK; Pitts, WJ; Kumar, SR; Gardner, DS; Murugesan, N; Paidi, VR; Santella, JB; Sistla, RK; Wu, H Heteroaryl substituted pyridyl compounds useful as kinase modulators US Patent  US10544133 Publication Date 1/28/2020 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM283924
Synonyms:
US10023562, Example 116 | US10544133, Example 116 | US9657009, 116
Type:
Small organic molecule
Emp. Form.:
C25H32FN7O2
Mol. Mass.:
481.5657
SMILES:
CC(C)NC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnc(Nc2ncc(cc2F)C#N)cc1NC(C)C |r,wU:9.12,wD:6.5,(-11.34,1.15,;-10,1.93,;-10,3.47,;-8.67,1.15,;-7.34,1.93,;-7.34,3.47,;-6,1.15,;-6,-.38,;-4.67,-1.15,;-3.33,-.38,;-3.33,1.15,;-4.67,1.93,;-2,-1.15,;-.67,-.38,;-.67,1.15,;.67,-1.15,;.67,-2.69,;2,-3.47,;3.33,-2.69,;4.67,-3.47,;6,-2.69,;7.34,-3.47,;8.67,-2.69,;8.67,-1.15,;7.34,-.38,;6,-1.15,;4.67,-.38,;10,-.38,;11.34,-1.15,;3.33,-1.15,;2,-.38,;2,1.15,;3.33,1.93,;3.33,3.47,;4.67,1.15,)|
Structure:
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