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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM283959
Substrate
n/a
Meas. Tech.
IRAK4 Inhibition Assay
IC50
3.30±n/a nM
Citation
 Bhide, RS; Duncia, JV; Hynes, J; Nair, SK; Pitts, WJ; Kumar, SR; Gardner, DS; Murugesan, N; Paidi, VR; Santella, JB; Sistla, RK; Wu, H Heteroaryl substituted pyridyl compounds useful as kinase modulators US Patent  US10544133 Publication Date 1/28/2020 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM283959
Synonyms:
US10023562, Example 151 | US10544133, Example 151 | US9657009, 151
Type:
Small organic molecule
Emp. Form.:
C22H25ClN6O3S
Mol. Mass.:
488.99
SMILES:
CS(=O)(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnc(Nc2ncc(cc2Cl)C#N)cc1NC1CC1 |r,wU:7.10,wD:4.3,(-10,1.26,;-8.67,2.03,;-9.44,3.36,;-7.9,3.36,;-7.34,1.26,;-7.34,-.28,;-6,-1.05,;-4.67,-.28,;-4.67,1.26,;-6,2.03,;-3.33,-1.05,;-2,-.28,;-2,1.26,;-.67,-1.05,;-.67,-2.59,;.67,-3.36,;2,-2.59,;3.33,-3.36,;4.67,-2.59,;6,-3.36,;7.34,-2.59,;7.34,-1.05,;6,-.28,;4.67,-1.05,;3.33,-.28,;8.67,-.28,;10,-1.05,;2,-1.05,;.67,-.28,;.67,1.26,;2,2.03,;3.54,2.03,;2.77,3.36,)|
Structure:
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