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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM427201
Substrate
n/a
Meas. Tech.
S1P1 assay
EC50
4100±n/a nM
Citation
 Roberts, E; Rosen, H; Brown, S; Guerrero, MA; Peng, X; Poddutoori, R Modulators of sphingosine phosphate receptors US Patent  US10544136 Publication Date 1/28/2020 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM427201
Synonyms:
US10544136, Compound 5
Type:
Small organic molecule
Emp. Form.:
C15H10F3N3O
Mol. Mass.:
305.2546
SMILES:
FC(F)(F)c1ccc(cc1)-c1noc(Cc2ccncc2)n1
Structure:
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