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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM427236
Substrate
n/a
Meas. Tech.
S1P1 assay
EC50
1480±n/a nM
Citation
 Roberts, E; Rosen, H; Brown, S; Guerrero, MA; Peng, X; Poddutoori, R Modulators of sphingosine phosphate receptors US Patent  US10544136 Publication Date 1/28/2020 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM427236
Synonyms:
US10544136, Compound 45
Type:
Small organic molecule
Emp. Form.:
C15H11Cl2N3O2
Mol. Mass.:
336.173
SMILES:
COc1cc(ccc1C)-c1noc(n1)-c1cc(Cl)nc(Cl)c1
Structure:
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