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Target
Protein P
Ligand
BDBM427509
Substrate
n/a
Meas. Tech.
HBV Replication Inhibition Assay
EC50
750±n/a nM
Citation
 Hartman, GD; Kuduk, S Derivatives and methods of treating hepatitis B infections US Patent  US10544141 Publication Date 1/28/2020 
Target
Name:
Protein P
Synonyms:
P | Q9WRL0_HBV | polymerase
Type:
Protein
Mol. Mass.:
94822.25
Organism:
HBV
Description:
Q9WRL0
Residue:
845
Sequence:
MPLSYQHFRKLLLLDDGTEAGPLEEELPRLADADLNRRVAEDLNLGNPNVSIPWTHKVGNFTGLYSSTVPIFNPEWQTPSFPKIHLQEDIINRCEQFVGPLTVNEKRRLKLIMPARFYPTHTKYLPLDKGIKPYYPDQVVNHYFQTRHYLHTLWKAGILYKRETTRSASFCGSPYSWEQELQHGRLVIKTSQRHGDESFCSQPSGILSRSSVGPCIRSQLKQSRLGLQPHQGPLASSQPGRSGSIRARVHPSTRRCFGVEPSGSGHVDPSVNNSSSCLRQSAVRKAAHSHLSTSKRQSSSGDAVEFHCLPPSSARPQSQGSVFSCWWLQFRNSKPCSEYCLSHIVNLREDWGPCDEHGEHHIRIPRTPARVTGGVFLVDKNPHNTEESRLVVDFSQFSRGITRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHIPLHPAAMPHLLIGSSGLSRYVARLSSNSRINNNQYGTMQNLHDSCSRQLYVSLMLLYKTYGWKLHLYSHPIVLGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKTVQHRESLYTAVTNFLLSLGIHLNPNKTKRWGYSLNFMGYVIGSWGTLPQDHIVQKIKHCFRKLPVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSPTYKAFLSKQYMNLYPVARQRPGLCQVFADATPTGWGLAIGHQRMRGTFVAPLPIHTAELLAACFARSRSGAKLIGTDNSVVLSRKYTSFPWLLGCAANWILRGTSFVYVPSALNPADDPSRGRLGLSRPLLRLPFQPTTGRTSLYAVSPSVPSHLPVRVHFASPLHVAWRPP
  
Inhibitor
Name:
BDBM427509
Synonyms:
US10544141, Compound 968
Type:
Small organic molecule
Emp. Form.:
C17H19BrFN5O2
Mol. Mass.:
424.267
SMILES:
CC1Cc2[nH]nc(C3CCCO3)c2CN1C(=O)Nc1ccnc(Br)c1F
Structure:
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