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Target
Neuroepithelial cell-transforming gene 1 protein
Ligand
BDBM433782
Substrate
n/a
Meas. Tech.
Functional Uptake Assay (hNET)
IC50
23.0±n/a nM
Citation
 Shao, L; Wang, F; Malcolm, SC; Hewitt, MC; Bush, LR; Ma, J; Varney, MA; Campbell, U; Engel, SR; Hardy, LW; Koch, P; Campell, JE Cycloalkylamines as monoamine reuptake inhibitors US Patent  US10562878 Publication Date 2/18/2020 
Target
Name:
Neuroepithelial cell-transforming gene 1 protein
Synonyms:
ARHG8_HUMAN | ARHGEF8 | NET1 | Proto-oncogene p65 Net1 | Rho guanine nucleotide exchange factor 8
Type:
PROTEIN
Mol. Mass.:
67762.41
Organism:
Homo sapiens
Description:
ChEMBL_118125
Residue:
596
Sequence:
MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPNWDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
  
Inhibitor
Name:
BDBM433782
Synonyms:
US10562878, Compound 224 | US10562878, Compound 225
Type:
Small organic molecule
Emp. Form.:
C20H27NO
Mol. Mass.:
297.4345
SMILES:
CN(C)CC1(CCC(C)(O)CC1)c1ccc2ccccc2c1 |(1.45,3.81,;.46,2.63,;-1.05,2.89,;.99,1.18,;;-.53,-1.45,;-2.04,-1.71,;-3.03,-.53,;-4.5,-.06,;-4.25,-1.48,;-2.51,.91,;-.99,1.18,;1.33,-.77,;1.33,-2.31,;2.67,-3.08,;4,-2.31,;5.33,-3.08,;6.67,-2.31,;6.67,-.77,;5.33,,;4,-.77,;2.67,,)|
Structure:
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