Reaction Details Report a problem with these data
Target
Neuroepithelial cell-transforming gene 1 protein
Ligand
BDBM433833
Substrate
n/a
Meas. Tech.
Functional Uptake Assay (hNET)
IC50
33.0±n/a nM
Citation
 Shao, L; Wang, F; Malcolm, SC; Hewitt, MC; Bush, LR; Ma, J; Varney, MA; Campbell, U; Engel, SR; Hardy, LW; Koch, P; Campell, JE Cycloalkylamines as monoamine reuptake inhibitors US Patent  US10562878 Publication Date 2/18/2020 
Target
Name:
Neuroepithelial cell-transforming gene 1 protein
Synonyms:
ARHG8_HUMAN | ARHGEF8 | NET1 | Proto-oncogene p65 Net1 | Rho guanine nucleotide exchange factor 8
Type:
PROTEIN
Mol. Mass.:
67762.41
Organism:
Homo sapiens
Description:
ChEMBL_118125
Residue:
596
Sequence:
MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPNWDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
  
Inhibitor
Name:
BDBM433833
Synonyms:
US10562878, Compound 293
Type:
Small organic molecule
Emp. Form.:
C19H23N
Mol. Mass.:
265.3926
SMILES:
CN(C)CC1(CCC=CC1)c1ccc2ccccc2c1 |c:7|
Structure:
Search PDB for entries with ligand similarity: