Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM297697
Substrate
n/a
Meas. Tech.
NTR1 Ca2+ Flux Dose Response
EC50
6000±n/a nM
Citation
 Pinkerton, AB; Hershberger, PM; Peddibhotla, S; Maloney, PR; Hedrick, MP Small molecule agonists of neurotensin receptor 1 US Patent  US10584103 Publication Date 3/10/2020 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM297697
Synonyms:
1-{2-(1-Fluoro-cyclobutyl)-4-[4- (2-methoxy-phenyl)-piperidin-1- yl]-pyrido[3,4-d]pyrimidin-6-yl}- pyrrolidin-3-ol | US10118902, Example 200 | US10584103, Example 200
Type:
Small organic molecule
Emp. Form.:
C27H32FN5O2
Mol. Mass.:
477.5737
SMILES:
COc1ccccc1C1CCN(CC1)c1nc(nc2cnc(cc12)N1CC[C@H](O)C1)C1(F)CCC1 |r|
Structure:
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