Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM435189
Substrate
n/a
Meas. Tech.
NTR1 Ca2+ Flux Dose Response
EC50
6000±n/a nM
Citation
 Pinkerton, AB; Hershberger, PM; Peddibhotla, S; Maloney, PR; Hedrick, MP Small molecule agonists of neurotensin receptor 1 US Patent  US10584103 Publication Date 3/10/2020 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM435189
Synonyms:
2-{1-[6-{[2-(tert-Butyl-dimethyl- silanyloxy)-ethyl]-methyl-amino}- 2-(1-fluoro-cyclopropyl)- quinazolin-4-yl]-piperidin-4-yl}- phenol | US10584103, Example 224
Type:
Small organic molecule
Emp. Form.:
C25H29FN4O2
Mol. Mass.:
436.5218
SMILES:
CN(CCO)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3O)c2c1)C1(F)CC1
Structure:
Search PDB for entries with ligand similarity: