Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4 [460-802]
Ligand
BDBM436174
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<10±n/a nM
Citation
 Kong, NX; Zhou, C; Zheng, Z Heterocyclic compounds used as FGFR inhibitors US Patent  US10590109 Publication Date 3/17/2020 
Target
Name:
Fibroblast growth factor receptor 4 [460-802]
Synonyms:
FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor 4 (FGFR4)(aa 460-802) | JTK2 | TKF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37991.56
Organism:
Homo sapiens (Human)
Description:
aa 460-802
Residue:
343
Sequence:
WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM436174
Synonyms:
US10590109, Compound 1
Type:
Small organic molecule
Emp. Form.:
C22H14F3N3O2
Mol. Mass.:
409.3607
SMILES:
FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(Oc2ccc3nccnc3c2)c1
Structure:
Search PDB for entries with ligand similarity: