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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM438728
Substrate
n/a
Meas. Tech.
BRD4 AlphaScreen Assay
IC50
<25±n/a nM
Citation
 Combs, AP; Sparks, RB Tricyclic heterocycles as BET protein inhibitors US Patent  US10618910 Publication Date 4/14/2020 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM438728
Synonyms:
(4S)-2-[(3S)-4-acetyl-3-methylpiperazin-1- yl]-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin- 2-yl-4,5-dihydroimidazo[1,5,4- de][1,4]benzoxazine | US10618910, Example 7
Type:
Small organic molecule
Emp. Form.:
C26H28N6O3
Mol. Mass.:
472.5389
SMILES:
C[C@@H]1CN(CCN1C(C)=O)c1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccn4)n1c23 |r,wD:26.28,1.0,(.88,6.45,;.09,5.14,;.81,3.77,;-.01,2.47,;-1.55,2.47,;-2.27,3.77,;-1.45,5.14,;-2.21,6.48,;-3.75,6.49,;-1.43,7.8,;.62,1.12,;2.27,.96,;2.59,-.55,;3.92,-1.32,;3.92,-2.86,;2.59,-3.63,;2.59,-5.17,;3.83,-6.07,;5.3,-5.59,;3.36,-7.53,;1.82,-7.53,;1.34,-6.07,;-.12,-5.59,;1.25,-2.86,;-.08,-3.63,;-1.41,-2.86,;-1.41,-1.32,;-2.75,-.55,;-2.75,.99,;-4.08,1.76,;-5.42,.99,;-5.42,-.55,;-4.08,-1.32,;-.08,-.55,;1.25,-1.32,)|
Structure:
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