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Target
Arginase-1
Ligand
BDBM290414
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2000±n/a nM
Citation
 Van Zandt, M; Jagdmann, GE Arginase inhibitors as therapeutics US Patent  US10603330 Publication Date 3/31/2020 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM290414
Synonyms:
(3R,4S)-3-amino-1-(2-aminophenylsulfonyl)-4-(3- boronopropyl)pyrrolidine-3-carboxylic acid | US10098902, Example 50 | US10603330, Example 50 | US11389464, Example 50
Type:
Small organic molecule
Emp. Form.:
C14H22BN3O6S
Mol. Mass.:
371.217
SMILES:
Nc1ccccc1S(=O)(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O |r|
Structure:
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