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Target
Kappa-type opioid receptor
Ligand
BDBM168147
Substrate
n/a
Meas. Tech.
Radioligand Competition Binding Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
5.00±n/a nM
Comments
extracted
Citation
 Duarte, FJ; Anand, NK; Sharma, P; Singh, D Opioid agonists and uses thereof US Patent  US9688638 Publication Date 6/27/2017 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM168147
Synonyms:
US10081602, Example 12 | US9688638, 12
Type:
Small organic molecule
Emp. Form.:
C35H51N3O6
Mol. Mass.:
609.7959
SMILES:
COCCOCCOCCOCCOCCNc1ccc(Nc2ccc3C(=O)C4[C@H](C)[C@@](C)(CCN4CC4CC4)c3c2)cc1 |r,TLB:30:29:26.40.25:35.34.33|
Structure:
Search PDB for entries with ligand similarity: