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Target
OTU domain-containing protein 7B
Ligand
BDBM443248
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
550±n/a nM
Citation
 Kemp, MI; Stockley, ML; Woodrow, MD; Jones, A Spiro-condensed pyrrolidine derivatives as deubiquitylating enzymes (DUB) inhibitors US Patent  US10654853 Publication Date 5/19/2020 
Target
Name:
OTU domain-containing protein 7B
Synonyms:
Cellular zinc finger anti-NF-kappa-B protein | Cezanne | OTU7B_HUMAN | OTUD7B | ZA20D1 | Zinc finger A20 domain-containing protein 1 | Zinc finger protein Cezanne
Type:
Protein
Mol. Mass.:
92527.32
Organism:
Human
Description:
Q6GQQ9
Residue:
843
Sequence:
MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQLRQVHAGNLPPSFSEGSGGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHASSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSMLVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALYALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTNGANCGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFAVDPGKGWEWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESPTASAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEAAGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQEEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAESRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPYPHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPTQTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLVHRF
  
Inhibitor
Name:
BDBM443248
Synonyms:
7'-(5-Fluoro-2- isopropoxyphenyl)-2'-oxo- 1',4'-dihydro-2'H- spiro[pyrrolidine-3,3'- quinoline]-1-carbonitrile | US10654853, Example 21
Type:
Small organic molecule
Emp. Form.:
C22H22FN3O2
Mol. Mass.:
379.4274
SMILES:
CC(C)Oc1ccc(F)cc1-c1ccc2CC3(CCN(C3)C#N)C(=O)Nc2c1
Structure:
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