Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM444446
Substrate
n/a
Meas. Tech.
Fluorescent Assay
IC50
>1000±n/a nM
Citation
 Makriyannis, A; Malamas, M; Lamani, M; Farah, SI ABHD6 and dual ABHD6/MGL inhibitors and their uses US Patent  US10662159 Publication Date 5/26/2020 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM444446
Synonyms:
US10662159, Example 31
Type:
Small organic molecule
Emp. Form.:
C16H16F6N2O4S
Mol. Mass.:
446.365
SMILES:
FC(F)(F)C(OC(=O)N1Cc2ccc(cc2C1)N1CCS(=O)(=O)CC1)C(F)(F)F
Structure:
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